Proposed Rule: Topramezone Posting Memo for Public Participation Regulations.gov Document ID: <a href="https://www.regulations.gov/document/EPA-HQ-OPP-2025-3291-0001" target="_self"><ins>EPA-HQ-OPP-2025-3291-0001</ins></a> Comment Period: June 26, 2026 to July 27, 2026 Agency: U.S. Environmental Protection Agency (EPA)
View the <a href="https://www.regulations.gov/user-notice" target="_self"><ins>terms of participation</ins></a> and <a href="https://www.regulations.gov/privacy-notice" target="_self"><ins>privacy notice</ins></a> for Regulations.gov. All comments made on <a href="http://regulations.gov" target="_self"><ins>regulations.gov</ins></a> action centers will be public comments, so we encourage action-takers not to include personally identifiable information in their messages.
ARE YOU SICK AND TIRED OF THE HYPOCRISY, LIES AND BLATANT GASLIGHTING YET?
Trump’s EPA sent out an absurd email saying the agency, in support of Regenerative Agriculture, is proposing to approve new and expanded uses of two very toxic herbicides—isoxaflutole and topramezone—for over-the-top spraying on GMO cotton.
You can’t make this stuff up.
The EPA says, “These tools help farmers manage economically damaging, herbicide-resistant weeds like Palmer amaranth, and they support regenerative, soil-health practices such as no-till farming — an alternative to intensive tillage that increases runoff and erosion.”
The EPA must truly think Americans are stupid. Regenerative organic farmers prove that no-till farming can be achieved without any pesticides at all. And studies show that pesticides harm soil health by killing the myriad of organisms that contribute to a vibrant soil food web.
Bayer-Monsanto and other chemical corporations have been pushing the notion that no-till farming is only possible by using synthetic pesticides, claiming these pesticides are necessary for regenerative agriculture. It’s complete nonsense.
To ensure its survival, the agrichemical industry is working aggressively to co-opt, redefine, and control the narrative around regenerative agriculture, transforming a movement rooted in reducing chemical dependence into one that preserves heavy use of its toxic pesticides, synthetic fertilizers, and genetically engineered seeds.
EPA management, now fully stacked with chemical lobbyists, is using the agency to perpetuate this false narrative. Don’t be fooled.
TOPRAMEZONE
Topramezone is linked to thyroid issues, liver damage, and pancreatic degeneration.
It is also highly mobile in soil, potentially harming important soil-dwelling organisms like earthworms, and has a high risk of leaching into groundwater and harming aquatic ecosystems. The EU has indicated a high potential for groundwater exposure above the parametric drinking water limit, which raises concerns about long-term exposure through drinking water.
Expanding the use of this synthetic herbicide for over-the-top spraying on topramezone-tolerant GMO cotton will increase the use of this chemicals by millions of pounds annually.
Regenerative agriculture improves soil health, protects biodiversity, reduces reliance on harmful agricultural chemicals, and improves human health outcomes. Expanding the use of pesticides that are toxic to plants, pose risks to wildlife, and can harm human health bears little resemblance to the widely recognized goals of regenerative agriculture.
We must resoundingly reject the EPA’s plan to expand and increase the new uses of these toxic pesticides. EPA’s brand of so-called “regenerative agriculture” is destructive, not regenerative. Let this chemical-lobbyist infested EPA know what you think.
Submit a comment to both regulatory comment dockets today. The pre-written comments are editable so you can make them your own. The public comment deadline is Monday, July 27, 2026 at 11:59PM Eastern.
After submitting your comment for topramezone, <a href="https://mstr.app/cc38e631-49d2-4fa6-a028-5716bf4f154e" target="_blank">GO HERE</a> to submit your comment for isoxaflutole if you haven’t already done so.

TRUMP EPA CLAIMS TO SUPPORT “REGENERATIVE” AGRICULTURE BY APPROVING NEW TOXIC PESTICIDE USE: TOPRAMEZONE. HUH?

I urge EPA to deny the proposed registration allowing over-the-top spraying of topramezone on genetically engineered cotton.

Regenerative agriculture should promote healthy soils, cleaner water, thriving wildlife, and resilient farming systems—not greater dependence on herbicides. Topramezone has been associated with thyroid and liver toxicity, is highly mobile in soil, and has the potential to reach groundwater, creating concerns for long-term environmental and human exposure.

Approving this proposal would increase herbicide use while undermining the principles EPA claims to support. EPA must reject this proposal and encourage agricultural practices that reduce the need for hazardous pesticides instead of practices that support only the bottom line of chemical companies.

Action REG Federal EPA-HQ-OPP-2025-3291-0001 Topramezone

GMO/Toxin Free USA

I strongly oppose EPA's proposal to approve over-the-top applications of topramezone on genetically engineered cotton. Expanding the use of another synthetic herbicide is not regenerative agriculture—it is the opposite.

Regenerative agriculture is intended to restore soil health, increase biodiversity, and reduce reliance on synthetic pesticides. Increasing the use of topramezone, which has been linked to thyroid effects, liver damage, and pancreatic degeneration, moves agriculture in the wrong direction. The herbicide's mobility in soil and potential to leach into groundwater also raise serious concerns for drinking water and aquatic ecosystems.

EPA should reject this proposal and support truly regenerative farming systems that reduce dependence on toxic agricultural chemicals instead of expanding them.

Do not approve topramezone use on GMO cotton

The EPA must reject this proposal to expand the use of topramezone on herbicide-tolerant GMO cotton. Calling increased herbicide use "regenerative agriculture" misrepresents a movement that is built on improving soil health and reducing chemical inputs.

Topramezone can move through soil, posing risks to soil organisms and increasing the potential for groundwater contamination. Expanding its use by millions of pounds each year threatens soil health, water quality, and biodiversity while increasing unnecessary chemical dependence.

True regenerative agriculture reduces reliance on synthetic pesticides. This proposal does the exact opposite and should be denied.

Reject topramezone use on GMO cotton

NO to topramezone on genetically engineered cotton

I oppose EPA's proposal to expand the use of topramezone on GMO cotton. Increasing the use of synthetic herbicides should not be described as regenerative agriculture. Regenerative farming seeks to reduce dependence on pesticides while protecting soil biology, biodiversity, and human health.

Topramezone presents important environmental and health concerns, including potential effects on the thyroid, liver, and pancreas, along with its ability to move through soil and potentially contaminate groundwater. Increasing its use also places greater pressure on beneficial soil organisms and aquatic ecosystems.

EPA should reject this proposal and stop using the term "regenerative agriculture" to justify policies that expand the use of toxic herbicides rather than reduce them.

Approving topramezone for use on GMO cotton is NOT regenerative agriculture